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              DISEASE MOUSE MODELS

              Model animals, as an important tool for human disease research, aid in the investigation of disease mechanisms and the development of therapies. Mouse models, being the most extensively used model animals, are employed in a variety of areas, such as fundamental scientific research, drug discovery, preclinical evaluation, and clinical technology development. Mice have a close relationship with humans, advanced genetic manipulation, fast reproduction, and a clear genetic background. Gene editing technology can provide suitable disease models for study based on disease-related genes. GemPharmatech has produced numerous disease models using gene editing technologies, such as spontaneous tumor models, obesity models, diabetes models, Alzheimer's disease models, Parkinson's disease models, and so on. Through phenotypic analysis, GemPharmatech has also confirmed the incidence and development of numerous model-related phenotypes, providing solid support for the research of various diseases.

              Introducing GemPharmatech's Latest Strains: Unveiling the Future of Innovation


              Strain ID

              Strain Name

              Application

              T055223


              B6-Tg(hSOD1 G93A,hSOD1) 圖片1.png

              Genetic humanization, ALS disease

              T058996

              FAD4T-hTREM2 圖片1.png

              Genetic humanization, Alzheimer's disease

              T054322

              B6-hSNCA E46K A53T

              Genetic humanization, Parkinson's disease

              T056757

              B6-hCD36

              Genetic humanization, neuroinflammation

              T056002

              B6-Dmd Del45

              Duchenne muscular dystrophy, 45 exon deletion

              T055631

              B6-hDLL4

              Genetic humanization, oncology

              T056429

              B6-hCD34

              Genetic humanization, oncology

              T058753

              B6-hCEACAM5-Tg

              Genetic humanization, oncology

              T053316

              B6-hIL18R1/hIL18RAP

              Genetic humanization, oncology

              T037007

              B6-hCD47/hSIRPA 圖片1.png

              Genetic humanization, oncology

              T056010

              BALB/c-hCD44

              Genetic humanization, oncology

              T054198

              BALB/c-hGPC3

              Genetic humanization, oncology

              T054490

              BALB/c-hSEMA4D

              Genetic humanization, oncology

              T054543

              BALB/c-hHSA

              Genetic humanization, oncology

              T056432

              BALB/c-hTROP2 圖片1.png

              Genetic humanization, oncology

              T056011

              BALB/c-hCD44v6

              Genetic humanization, oncology

              T055714

              BALB/c-hCS1

              Genetic humanization, oncology

              T056083

              BALB/c-hLRRC15

              Genetic humanization, oncology

              T056430

              BALB/c-hNECTIN-4

              Genetic humanization, oncology

              T058266

              BALB/c-hTIGIT/hPVRIG

              Genetic humanization, oncology

              T054842

              BALB/c-hPD1/hPDL1/hTIGIT/hCD9 圖片1.png

              Genetic humanization, oncology

              T058749

              BALB/c-hPD1/hPDL1/hCD73/hCD39 圖片1.png

              Genetic humanization, oncology

              T009819


              BALB/c-hHER2 圖片1.png


              Genetic humanization, oncology

              T009813

              NCG-hHER2

              Genetic humanization, oncology

              T054081

              NOD-Scid-hNKp30

              Genetic humanization, oncology

              T056195

              B6-hIGHA1

              Genetic humanization, autoimmune disease


              T054583

              BALB/c-hIL1RL1

              Genetic humanization, autoimmune disease

              T054645

              BALB/c-hKLRB1

              Genetic humanization, autoimmune disease

              T003277

              BALB/c-hIL17A 圖片1.png

              Genetic humanization, autoimmune disease

              T053555

              BALB/c-hIL1β

              Genetic humanization, autoimmune disease

              T054186

              BALB/c-hTLR8

              Genetic humanization, autoimmune disease

              T055268

              BALB/c-hFcgRs/hCD47/hSIRPA 圖片1.png

              Genetic humanization, Fc end modification for antibody drugs, ADCC effect

              T058940

              BALB/c-hCD3EDG/hCD22

              Genetic humanization, CD3 bispecific antibody related

              T057420

              BALB/c-hCD73/hCD3EDG 

              Genetic humanization, CD3 bispecific antibody related

              T058817

              BALB/c-hGPRC5D/hCD3EDG 圖片1.png

              Genetic humanization, CD3 bispecific antibody related

              T059045

              BALB/c-hCD3EDG/hBCMA 圖片1.png

              Genetic humanization, CD3 bispecific antibody related

              T058351

              B6-Rosa26-hAGT 圖片1.png

              Genetic humanization, hypertension

              T058352

              B6-H11-hREN

              Genetic humanization, hypertension

              T054639

              B6-hCD200R1

              Genetic humanization, atherosclerosis research

              T058217

              B6-hAPOB-Tg

              Genetic humanization, hypercholesteremia and atherogenesis

              T058211

              B6-hAPOE-DGAT2-LE1 圖片1.png

              Genetic humanization, NASH

              T051403

              B6-Myh6-R404Q 圖片1.png

              Hypertrophic cardiomyopathy

              T027708

              B6-Mybpc3-KO

              hypertrophic cardiomyopathy or dilated cardiomyopathy

              T007085

              B6-Kras-G12D/wt; Lyz2-iCre

              Spontaneous lung cancer

              T053603

              kras-G12C 圖片1.png

              Kras-related spontaneous tumors

              T057165

              KPS 圖片1.png

              Spontaneous lung cancer

              T057162

              KS

              Spontaneous lung cancer


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